Mike Santiago has 14 losses against 14 opponents on his MMA record. For a list of Santiago's best fights, refer to "Best fights of Mike Santiago".
On July 31, 2020 Mike Santiago faced off against Bruno Machado in a lightweight bout at age 31. He was coming in with a record of 22-14 (16). Santiago lost the fight via 2nd-round choke-out.
On November 16, 2019 Mike Santiago faced off against Timur Nagibin in a lightweight bout at age 30. He was coming in with a record of 22-13 (16). Santiago lost the fight via 2nd-round TKO.
On June 9, 2018 Mike Santiago faced off against Dan Ige in a lightweight bout at age 28. He was coming in with a record of 21-12 (15), and Ige was 26 years old and with a record of 8-2 (6). Santiago lost the fight via 1st-round TKO.
On January 14, 2018 Mike Santiago faced off against Mads Burnell in a lightweight bout at age 28. He was coming in with a record of 21-11 (15), and Burnell was 23 years old and with a record of 8-2 (5). Santiago lost the fight via 3-round unanimous decision.
On September 2, 2017 Mike Santiago faced off against Zabit Magomedsharipov in a lightweight bout at age 28. He was coming in with a record of 21-10 (15), and Magomedsharipov was 26 years old and with a record of 12-1 (10). Santiago lost the fight via 2nd-round submission.
On January 24, 2014 Mike Santiago faced off against Frankie Perez in a lightweight bout at age 24. He was coming in with a record of 10-9 (6). Santiago lost the fight via 21st-round submission.
On August 17, 2013 Mike Santiago faced off against Mike Medrano in a lightweight bout at age 24. He was coming in with a record of 10-8 (6). Santiago lost the fight via 1st-round submission.
On June 14, 2013 Mike Santiago fought Phillipe Nover in a lightweight title fight for the ROC Championship title. Santiago was 23 years old and with a record of 10-7 (6), and Nover was 29 years old and with a record of 8-5-1 (5). Santiago lost the fight via 3-round unanimous decision.
On September 14, 2012 Mike Santiago fought Deividas Taurosevicius in a featherweight title fight for Taurosevicius' ROC Championship title. Santiago was 23 years old and with a record of 8-6 (5), and Taurosevicius was 35 years old and with a record of 14-5 (8). Santiago lost the fight via 2nd-round submission.
On April 13, 2012 Mike Santiago faced off against Taurean Bogguess in a featherweight bout at age 22. He was coming in with a record of 7-5 (4). Santiago lost the fight via 3-round unanimous decision.
On October 15, 2011 Mike Santiago faced off against Josh Shockley in a featherweight bout at age 22. He was coming in with a record of 5-4 (2), and Shockley was 21 years old and with a record of 6-1 (5). Santiago lost the fight via 1st-round submission.
On July 29, 2011 Mike Santiago faced off against Brendan Weafer in a featherweight bout at age 22. He was coming in with a record of 5-3 (2). Santiago lost the fight via 1st-round TKO.
On March 4, 2011 Mike Santiago faced off against Eric Kriegermeier in a featherweight bout at age 21. He was coming in with a record of 4-2 (2). Santiago lost the fight via 2nd-round submission.
On August 14, 2010 Mike Santiago faced off against Donavon Winters in a featherweight bout at age 21. He was coming in with a record of 2-1 (0). Santiago lost the fight via 2nd-round TKO.
