Here is a list of Santiago's best fights. For a list of Santiago's losses, refer to "Mike Santiago Losses".
On March 4, 2016 Mike Santiago met Lester Caslow in a featherweight (ROC Championship) title defense fight. Santiago was 26 years old and with a record of 17-9 (11), and Caslow was 31 years old and with a record of 15-10 (13). Santiago stopped Lester Caslow via 1st-round submission and successfully defended his title.
On January 23, 2015 Mike Santiago fought Kenny Foster in a featherweight title fight for the ROC Championship title. Santiago was 25 years old and with a record of 13-9 (8), and Foster was 29 years old and with a record of 11-9 (6). Santiago stopped Kenny Foster via 1st-round KO and is crowned the new featherweight world champion.
On June 17, 2016 Mike Santiago faced off against Luis Saldaña in a featherweight bout at age 26. He was coming in with a record of 18-9 (12), and Saldaña was 25 years old and with a record of 10-4 (10). Santiago stopped Luis Saldaña via TKO.
On April 15, 2017 Mike Santiago faced off against Nick Wayne in a lightweight bout at age 27. He was coming in with a record of 20-9 (14). Santiago stopped Nick Wayne via TKO.
On November 5, 2016 Mike Santiago faced off against Bill Kamery in a featherweight bout at age 27. He was coming in with a record of 19-9 (13). Santiago stopped Bill Kamery via submission.
