Here is a list of Ponzinibbio's best fights. For a list of Ponzinibbio's losses, refer to "Santiago Ponzinibbio Losses".
On April 16, 2016 Santiago Ponzinibbio faced off against Court McGee in a welterweight bout at age 29. He was coming in with a record of 22-3 (19), and McGee was 31 years old and with a record of 17-4 (10). Ponzinibbio stopped Court McGee via TKO.
On July 16, 2017 Santiago Ponzinibbio faced off against Gunnar Nelson in a welterweight bout at age 30. He was coming in with a record of 25-3 (20), and Nelson was 28 years old and with a record of 16-2-1 (15). Ponzinibbio stopped Gunnar Nelson via KO.
On December 10, 2015 Santiago Ponzinibbio faced off against Andreas Ståhl in a welterweight bout at age 29. He was coming in with a record of 21-3 (18). Ponzinibbio stopped Andreas Ståhl via TKO.
On December 10, 2022 Santiago Ponzinibbio faced off against Alex Morono in a welterweight bout at age 36. He was coming in with a record of 29-6 (22), and Morono was 32 years old and with a record of 22-7 (12). Ponzinibbio stopped Alex Morono via TKO.
On November 17, 2018 Santiago Ponzinibbio faced off against Neil Magny in a welterweight bout at age 32. He was coming in with a record of 27-3 (21), and Magny was 31 years old and with a record of 21-6 (10). Ponzinibbio stopped Neil Magny via KO.
On September 13, 2014 Santiago Ponzinibbio faced off against Wendell Oliveira in a welterweight bout at age 27. He was coming in with a record of 19-2 (17). Ponzinibbio stopped Wendell Oliveira via KO.
On February 22, 2015 Santiago Ponzinibbio faced off against Sean Strickland in a welterweight bout at age 28. He was coming in with a record of 20-2 (17), and Strickland was 23 years old and with a record of 15-0 (11). Ponzinibbio won the fight via 3-round unanimous decision.
On June 5, 2021 Santiago Ponzinibbio faced off against Miguel Baeza in a welterweight bout at age 34. He was coming in with a record of 28-4 (21). Ponzinibbio won the fight via 3-round unanimous decision.
On August 6, 2016 Santiago Ponzinibbio faced off against Zak Cummings in a welterweight bout at age 29. He was coming in with a record of 23-3 (19), and Cummings was 32 years old and with a record of 19-4 (14). Ponzinibbio won the fight via 3-round unanimous decision.
On January 11, 2025 Santiago Ponzinibbio faced off against Carlston Harris in a welterweight bout at age 38. He was coming in with a record of 30-8 (23), and Harris was 37 years old and with a record of 19-6 (8). Ponzinibbio stopped Carlston Harris via TKO.