Michael McDonald has four losses against four opponents on his MMA record. For a list of McDonald's best fights, refer to "Best fights of Michael McDonald".
On July 13, 2016 Michael McDonald faced off against John Lineker in a bantamweight bout at age 25. He was coming in with a record of 17-4 (15), and Lineker was 26 years old and with a record of 27-7 (16). McDonald lost the fight via 1st-round KO.
On December 14, 2013 Michael McDonald faced off against Urijah Faber in a bantamweight bout at age 22. He was coming in with a record of 16-3 (14), and Faber was 34 years old and with a record of 29-6 (21). McDonald lost the fight via 2nd-round submission.
On February 16, 2013 Michael McDonald fought Renan Barão in a bantamweight title fight for Barão's UFC Championship title. McDonald was 22 years old and with a record of 15-2 (13), and Barão was 26 years old and with a record of 29-1 (19). McDonald lost the fight via 4th-round submission.
On May 8, 2009 Michael McDonald faced off against Cole Escovedo at age 18. He was coming in with a record of 7-1 (7), and Escovedo was 27 years old and with a record of 11-4 (11). McDonald lost the fight via 2nd-round TKO.