Here is a list of Santiago's best fights. For a list of Santiago's losses, refer to "Jorge Santiago Losses".
On November 16, 2007 Jorge Santiago fought Trevor Prangley in a middleweight title fight for Prangley's Strikeforce Grand Prix title. Santiago was 27 years old and with a record of 16-7 (15), and Prangley was 35 years old and with a record of 17-4 (10). Santiago stopped Trevor Prangley via 1st-round TKO and is crowned the new Strikeforce middleweight champion.
On June 28, 2006 Jorge Santiago faced off against Justin Levens in a middleweight bout at age 25. He was coming in with a record of 12-5 (11), and Levens was 26 years old and with a record of 7-2 (7). Santiago stopped Justin Levens via KO.
On November 16, 2007 Jorge Santiago faced off against Sean Salmon in a middleweight bout at age 27. He was coming in with a record of 15-7 (14), and Salmon was 30 years old and with a record of 14-4 (12). Santiago stopped Sean Salmon via KO.
On February 27, 2004 Jorge Santiago faced off against Takuya Wada at age 23. He was coming in with a record of 7-2 (6), and Wada was 26 years old and with a record of 10-3-5 (4). Santiago stopped Takuya Wada via submission.
On November 1, 2008 Jorge Santiago faced off against Siyar Bahadurzada in a middleweight bout at age 28. He was coming in with a record of 19-7 (18), and Bahadurzada was 24 years old and with a record of 14-3-1 (11). Santiago stopped Siyar Bahadurzada via submission.
On September 28, 2008 Jorge Santiago faced off against Logan Clark in a middleweight bout at age 27. He was coming in with a record of 18-7 (17), and Clark was 23 years old and with a record of 12-2 (8). Santiago stopped Logan Clark via submission.
On September 1, 2007 Jorge Santiago faced off against Jeremy Horn in a middleweight bout at age 26. He was coming in with a record of 14-7 (13), and Horn was 32 years old and with a record of 79-15-5 (66). Santiago stopped Jeremy Horn via submission.
On August 22, 2010 Jorge Santiago faced off against Kazuo Misaki in a middleweight bout at age 29. He was coming in with a record of 23-8 (20), and Misaki was 34 years old and with a record of 22-10-2 (10). Santiago stopped Kazuo Misaki via TKO.
On April 14, 2007 Jorge Santiago faced off against Andrei Semenov in a middleweight bout at age 26. He was coming in with a record of 13-7 (12), and Semenov was 29 years old and with a record of 28-8-2 (25). Santiago stopped Andrei Semenov via TKO.
On January 24, 2004 Jorge Santiago faced off against John Cronk at age 23. He was coming in with a record of 6-2 (5). Santiago stopped John Cronk via submission.