Here is a list of Mayes's best fights. For a list of Mayes's losses, refer to "Don'Tale Mayes Losses".
On June 3, 2023 Don'Tale Mayes faced off against Andrei Arlovski in a heavyweight bout at age 31. He was coming in with a record of 10-5 (7), and Arlovski was 44 years old and with a record of 34-21 (20). Mayes stopped Andrei Arlovski via TKO.
On November 14, 2020 Don'Tale Mayes faced off against Roque Martinez in a heavyweight bout at age 28. He was coming in with a record of 8-4 (5), and Martinez was 34 years old and with a record of 15-6-2 (11). Mayes won the fight via 3-round unanimous decision.
On April 27, 2024 Don'Tale Mayes faced off against Caio Machado in a heavyweight bout at age 32. He was coming in with a record of 11-6 (7). Mayes won the fight via 3-round unanimous decision.
On December 18, 2021 Don'Tale Mayes faced off against Josh Parisian in a heavyweight bout at age 29. He was coming in with a record of 9-4 (6), and Parisian was 32 years old and with a record of 14-4 (12). Mayes stopped Josh Parisian via TKO.
On June 4, 2016 Don'Tale Mayes faced off against Arnold Adams in a heavyweight bout at age 24. He was coming in with a record of 2-0 (2), and Adams was 30 years old and with a record of 7-9 (5). Mayes stopped Arnold Adams via TKO.