Brian Ortega has five losses against five opponents on his MMA record. For a list of Ortega's best fights, refer to "Best fights of Brian Ortega".
On August 23, 2025 Brian Ortega faced off against Aljamain Sterling in a featherweight bout at age 34. He was coming in with a record of 16-5 (11), and Sterling was 36 years old and with a record of 24-5 (11). Ortega lost the fight via 5-round unanimous decision.
On September 14, 2024 Brian Ortega faced off against Diego Lopes in a featherweight bout at age 33. He was coming in with a record of 16-4 (11), and Lopes was 29 years old and with a record of 25-6 (22). Ortega lost the fight via 3-round unanimous decision.
On July 16, 2022 Brian Ortega faced off against Yair Rodríguez in a featherweight bout at age 31. He was coming in with a record of 15-3 (10), and Rodríguez was 29 years old and with a record of 17-3 (11). Ortega lost the fight via 1st-round TKO.
On September 25, 2021 Brian Ortega fought Alexander Volkanovski in a featherweight title fight for Volkanovski's UFC Championship title. Ortega was 30 years old and with a record of 15-2 (10), and Volkanovski was 32 years old and with a record of 22-1 (14). Ortega lost the fight via 5-round unanimous decision.
On December 8, 2018 Brian Ortega fought Max Holloway in a featherweight title fight for Holloway's UFC Championship title. Ortega was 27 years old and with a record of 14-1 (10), and Holloway was 27 years old and with a record of 19-3 (11). Ortega lost the fight via 4th-round TKO.
