René Santiago has four losses against four opponents on his boxing record. For a list of Santiago's best fights, refer to "Best fights of René Santiago".
On March 2, 2024 René Santiago fought Jonathan González in a light-flyweight world-title fight for González' WBO title. Santiago was 31 years old and with a record of 12-4 (9), and González was 32 years old and with a record of 27-3-1 (14). Santiago lost the fight via 12-round unanimous decision.
On April 8, 2022 René Santiago faced off against Yudel Reyes in a strawweight bout at age 29. He was coming in with a record of 9-3 (7). Santiago lost the fight via 10-round unanimous decision.
On December 7, 2018 René Santiago faced off against Geovani Garcia Barragan at age 26. He was coming in with a record of 6-2 (5). Santiago lost the fight via 6-round unanimous decision.
On January 30, 2016 René Santiago faced off against Waldemar Pagan at age 23. He was coming in with a record of 4-1 (3). Santiago lost the fight via 6-round unanimous decision.
