René Santiago (14-4, 9) was born in Humacao, Puerto Rico on April 10, 1992. At the age of 22 years on November 22, 2014, he made his professional boxing debut against Gustavo Ortiz, winning the fight via 4-round unanimous decision.
On his 16th career fight at 31 years old, René Santiago got a shot at the WBO light-flyweight titles against Jonathan González on March 2, 2024 but lost the fight via 12-round unanimous decision.
He became a light-flyweight world champion (WBO) on March 13, 2025 at the age of 32 years old, on his 18th career fight, after defeating Shokichi Iwata via 12-round unanimous decision.
Santiago's last fight was a light-flyweight world-title fight against Shokichi Iwata for Iwata's WBO title on March 13, 2025. He won the fight via 12-round unanimous decision and was crowned the new light-flyweight world champion. He is on a 2-fight winning streak.
René Santiago's best fight was against Shokichi Iwata.
Santiago has 4 losses on his boxing record. For details about these losses refer to "René Santiago Losses".
| # | Date | Opponent | Weight | Round | Method | Result |
|---|---|---|---|---|---|---|
18  | Mar 13, 2025 32 years, 11 months 14-4 (9) | 29 years, 1 months 14-1 (11) | LFL | 12 | UD | WIN Won WBO |
17 | Oct 30, 2024 32 years, 6 months 13-4 (9) | Ricardo Astuvilca | LFL | 12 | UD | WIN |
16  | Mar 2, 2024 31 years, 10 months 12-4 (9) | 32 years, 10 months 27-3-1 (14) | LFL | 12 | UD | LOSS For WBO |
15 | Oct 27, 2023 31 years, 6 months 12-3 (9) | Kevin Vivas | LFL | 12 | KO | WIN Won WBO Interim |
14 | Apr 14, 2023 31 years 11-3 (8) | Carlos Ortega | LFL | 9 | TKO | WIN |
13 | Dec 16, 2022 30 years, 8 months 10-3 (7) | Gerardo Zapata | LFL | 2 | DQ | WIN |
12 | Apr 8, 2022 29 years, 11 months 9-3 (7) | Yudel Reyes | ST | 10 | UD | LOSS |
11 | Nov 7, 2021 29 years, 6 months 9-2 (7) | Jose Calderon | LFL | 2 | TKO | WIN |
10 | Jan 31, 2020 27 years, 9 months 8-2 (6) | Israel Vazquez | LFL | 10 | UD | WIN |
9 | Nov 23, 2019 27 years, 7 months 7-2 (6) | Juan Gabriel Guzman Pichardo | 1 | TKO | WIN | |
8 | Dec 7, 2018 26 years, 7 months 6-2 (5) | Geovani Garcia Barragan | 6 | UD | LOSS | |
7 | Aug 25, 2018 26 years, 4 months 6-1 (5) | Jesus Miguel Martinez Castillo | 2 | TKO | WIN | |
6 | Jul 1, 2018 26 years, 2 months 5-1 (4) | Starlin Reyes Sierra | 1 | KO | WIN | |
5 | Jan 30, 2016 23 years, 9 months 4-1 (3) | Waldemar Pagan | 6 | UD | LOSS | |
4 | Aug 22, 2015 23 years, 4 months 4-0 (3) | Alberto Medina Maldonado | 2 | TKO | WIN | |
3 | May 31, 2015 23 years, 1 months 3-0 (2) | Alexis Diaz | 3 | TKO | WIN | |
2 | Apr 25, 2015 23 years 2-0 (1) | Luis Diaz | 2 | TKO | WIN | |
1 | Nov 22, 2014 22 years, 7 months 1-0 (0) | Gustavo Ortiz | 4 | UD | WIN |
