Juan Urango has three losses against three opponents on his boxing record. For a list of Urango's best fights, refer to "Best fights of Juan Urango".
On March 6, 2010 Juan Urango, the IBF champion, met Devon Alexander, the WBC champion, in a super-lightweight world-title unification fight. Urango was 29 years old and with a record of 22-3-1 (17), and Alexander was 23 years old and with a record of 19-0 (12). Urango lost the fight via 8th-round TKO and lost his title.
On May 30, 2009 Juan Urango fought Andre Berto in a welterweight world-title fight for Berto's WBC title. Urango was 28 years old and with a record of 21-2-1 (16), and Berto was 25 years old and with a record of 24-0 (19). Urango lost the fight via 12-round unanimous decision.
On January 20, 2007 Juan Urango met Ricky Hatton in a super-lightweight () world-title defense fight. Urango was 26 years old and with a record of 17-1-1 (13), and Hatton was 28 years old and with a record of 41-0 (30). Urango lost the fight via 12-round unanimous decision and lost the titles.