Simpiwe Vetyeka has four losses against four opponents on his boxing record. For a list of Vetyeka's best fights, refer to "Best fights of Simpiwe Vetyeka".
On October 21, 2017 Simpiwe Vetyeka faced off against Lerato Dlamini at age 36. He was coming in with a record of 29-4 (17). Vetyeka lost the fight via 10-round majority decision.
On May 31, 2014 Simpiwe Vetyeka met Nonito Donaire in a featherweight (WBA (Undisputed)) world-title defense fight. Vetyeka was 33 years old and with a record of 26-3 (16), and Donaire was 31 years old and with a record of 32-2 (21). Vetyeka lost the fight via 5-round technical decision and lost the title.
On June 4, 2012 Simpiwe Vetyeka faced off against Klaas Mboyane at age 31. He was coming in with a record of 23-2 (13). Vetyeka lost the fight via 8-round split decision.
On May 3, 2007 Simpiwe Vetyeka fought Hozumi Hasegawa in a bantamweight world-title fight for Hasegawa's WBC title. Vetyeka was 26 years old and with a record of 16-1 (9), and Hasegawa was 26 years old and with a record of 21-2 (7). Vetyeka lost the fight via 12-round unanimous decision.
