Here is a list of Vetyeka's best fights. For a list of Vetyeka's losses, refer to "Simpiwe Vetyeka Losses".
On December 6, 2013 Simpiwe Vetyeka fought Chris John in a featherweight world-title fight for John's titles. Vetyeka was 32 years old and with a record of 26-2 (16), and John was 34 years old and with a record of 48-0-3 (22). Vetyeka stopped Chris John via 6th-round retirement and is crowned the new featherweight world champion.
On April 14, 2013 Simpiwe Vetyeka faced off against Daud Yordan in a featherweight bout at age 32. He was coming in with a record of 25-2 (15), and Yordan was 25 years old and with a record of 30-2 (23). Vetyeka stopped Daud Yordan via TKO.
On February 25, 2011 Simpiwe Vetyeka faced off against Roberto Carlos Leyva at age 30. He was coming in with a record of 22-1 (13), and Leyva was 31 years old and with a record of 27-12-1 (21). Vetyeka stopped Roberto Carlos Leyva via KO.
On August 31, 2007 Simpiwe Vetyeka faced off against Ebenezer Tumane in a bantamweight bout at age 26. He was coming in with a record of 17-1 (10). Vetyeka stopped Ebenezer Tumane via TKO.