Todd Duffee has four losses against four opponents on his MMA record. For a list of Duffee's best fights, refer to "Best fights of Todd Duffee".
On February 25, 2023 Todd Duffee fought Phil De Fries in a heavyweight title fight for De Fries' KSW Championship title. Duffee was 37 years old and with a record of 9-4 (9), and De Fries was 36 years old and with a record of 22-6 (18). Duffee lost the fight via 1st-round TKO.
On July 15, 2015 Todd Duffee faced off against Frank Mir in a heavyweight bout at age 29. He was coming in with a record of 9-3 (9), and Mir was 36 years old and with a record of 17-9 (10). Duffee lost the fight via 1st-round KO.
On December 31, 2010 Todd Duffee fought Alistair Overeem in a heavyweight title fight for Overeem's DREAM Championship title. Duffee was 25 years old and with a record of 6-2 (6), and Overeem was 30 years old and with a record of 33-11 (32). Duffee lost the fight via 1st-round KO.
On May 29, 2010 Todd Duffee faced off against Mike Russow at age 24. He was coming in with a record of 6-1 (6), and Russow was 33 years old and with a record of 12-1 (10). Duffee lost the fight via 3rd-round KO.
