Sergey Khandozhko has six losses against six opponents on his MMA record. For a list of Khandozhko's best fights, refer to "Best fights of Sergey Khandozhko".
On November 9, 2019 Sergey Khandozhko faced off against Rustam Khabilov in a middleweight bout at age 27. He was coming in with a record of 26-6-1 (18), and Khabilov was 33 years old and with a record of 23-4 (9). Khandozhko lost the fight via 3-round unanimous decision.
On August 26, 2017 Sergey Khandozhko faced off against Stanislav Vlasenko in a middleweight bout at age 25. He was coming in with a record of 23-5-1 (16). Khandozhko lost the fight via 3rd-round submission.
On October 22, 2016 Sergey Khandozhko faced off against Benny Alloway in a middleweight bout at age 24. He was coming in with a record of 22-4-1 (16). Khandozhko lost the fight via 3rd-round submission.
On March 26, 2016 Sergey Khandozhko faced off against Patrik Kincl in a middleweight bout at age 23. He was coming in with a record of 21-3-1 (15). Khandozhko lost the fight via 3-round unanimous decision.
On June 14, 2015 Sergey Khandozhko faced off against Albert Duraev in a middleweight bout at age 23. He was coming in with a record of 20-2-1 (15). Khandozhko lost the fight via 3-round unanimous decision.
On May 25, 2013 Sergey Khandozhko faced off against Eduard Vartanyan in a lightweight bout at age 21. He was coming in with a record of 13-1-1 (11), and Vartanyan was 21 years old and with a record of 2-1 (2). Khandozhko lost the fight via 2nd-round TKO.