Sean Sherk has four losses against four opponents on his MMA record. For a list of Sherk's best fights, refer to "Best fights of Sean Sherk".
On May 23, 2009 Sean Sherk faced off against Frankie Edgar in a lightweight bout at age 35. He was coming in with a record of 35-4-1 (21), and Edgar was 27 years old and with a record of 10-1 (4). Sherk lost the fight via 3-round unanimous decision.
On May 24, 2008 Sean Sherk fought B.J. Penn in a lightweight title fight for Penn's UFC Championship title. Sherk was 34 years old and with a record of 34-3-1 (21), and Penn was 29 years old and with a record of 12-4-1 (9). Sherk lost the fight via 3rd-round TKO.
On November 19, 2005 Sean Sherk faced off against Georges St-Pierre in a welterweight bout at age 32. He was coming in with a record of 31-2-1 (21), and St-Pierre was 24 years old and with a record of 10-1 (8). Sherk lost the fight via 2nd-round TKO.
On April 25, 2003 Sean Sherk fought Matt Hughes in a welterweight title fight for Hughes' UFC Championship title. Sherk was 29 years old and with a record of 19-1-1 (10), and Hughes was 29 years old and with a record of 33-3 (27). Sherk lost the fight via 5-round unanimous decision.