Omar de la Cruz has three losses against three opponents on his MMA record. For a list of Cruz's best fights, refer to "Best fights of Omar de la Cruz".
On June 20, 2010 Omar de la Cruz faced off against Keita Nakamura in a welterweight bout at age 30. He was coming in with a record of 6-3 (4), and Nakamura was 26 years old and with a record of 18-4-2 (10). Cruz lost the fight via 2nd-round TKO.
On June 12, 2009 Omar de la Cruz faced off against Lyman Good in a welterweight bout at age 29. He was coming in with a record of 5-2 (3), and Good was 24 years old and with a record of 9-0 (4). Cruz lost the fight via 1st-round TKO.
On May 12, 2007 Omar de la Cruz faced off against Marcelo Brito at age 27. He was coming in with a record of 1-1 (1). Cruz lost the fight via 3-round split decision.