Mike Rodríguez has seven losses against seven opponents on his MMA record. For a list of Rodríguez's best fights, refer to "Best fights of Mike Rodríguez".
On September 18, 2021 Mike Rodríguez faced off against Tafon Nchukwi in a light-heavyweight bout at age 32. He was coming in with a record of 11-7 (11), and Nchukwi was 26 years old and with a record of 5-1 (4). Rodríguez lost the fight via 3-round unanimous decision.
On February 6, 2021 Mike Rodríguez faced off against Danilo Marques in a light-heavyweight bout at age 32. He was coming in with a record of 11-6 (11), and Marques was 35 years old and with a record of 10-2 (8). Rodríguez lost the fight via 2nd-round choke-out.
On September 12, 2020 Mike Rodríguez faced off against Ed Herman in a light-heavyweight bout at age 31. He was coming in with a record of 11-5 (11), and Herman was 39 years old and with a record of 25-14 (20). Rodríguez lost the fight via 3rd-round submission.
On December 21, 2019 Mike Rodríguez faced off against Da Un Jung in a light-heavyweight bout at age 31. He was coming in with a record of 10-4 (10). Rodríguez lost the fight via 1st-round KO.
On April 7, 2018 Mike Rodríguez faced off against Devin Clark in a light-heavyweight bout at age 29. He was coming in with a record of 9-3 (9), and Clark was 27 years old and with a record of 8-2 (4). Rodríguez lost the fight via 3-round unanimous decision.
On November 4, 2016 Mike Rodríguez faced off against Kevin Haley in a light-heavyweight bout at age 27. He was coming in with a record of 5-2 (5). Rodríguez lost the fight via 1st-round submission.
On January 8, 2016 Mike Rodríguez faced off against Pat McCrohan in a middleweight bout at age 27. He was coming in with a record of 2-1 (2). Rodríguez lost the fight via 3-round unanimous decision.