Matthew Lopez has four losses against four opponents on his MMA record. For a list of Lopez's best fights, refer to "Best fights of Matthew Lopez".
On December 8, 2018 Matthew Lopez faced off against Brad Katona at age 31. He was coming in with a record of 10-4 (8), and Katona was 26 years old and with a record of 7-0 (3). Lopez lost the fight via 3-round unanimous decision.
On April 14, 2018 Matthew Lopez faced off against Alejandro Pérez at age 31. He was coming in with a record of 10-3 (8), and Pérez was 28 years old and with a record of 19-6-1 (13). Lopez lost the fight via 2nd-round TKO.
On November 11, 2017 Matthew Lopez faced off against Raphael Assunção at age 30. He was coming in with a record of 10-2 (8), and Assunção was 35 years old and with a record of 25-5 (13). Lopez lost the fight via 3rd-round KO.
On July 13, 2016 Matthew Lopez faced off against Rani Yahya at age 29. He was coming in with a record of 8-1 (7), and Yahya was 31 years old and with a record of 21-8 (15). Lopez lost the fight via 3rd-round submission.