Mackenzie Dern has five losses against five opponents on her MMA record. For a list of Dern's best fights, refer to "Best fights of Mackenzie Dern".
On February 17, 2024 Mackenzie Dern faced off against Amanda Lemos in a strawweight bout at age 30. She was coming in with a record of 13-5 (7), and Lemos was 36 years old and with a record of 13-3-1 (10). Dern lost the fight via 3-round unanimous decision.
On November 11, 2023 Mackenzie Dern faced off against Jéssica Andrade in a strawweight bout at age 30. She was coming in with a record of 13-4 (7), and Andrade was 32 years old and with a record of 24-12 (17). Dern lost the fight via 2nd-round TKO.
On October 1, 2022 Mackenzie Dern faced off against Yan Xiaonan in a strawweight bout at age 29. She was coming in with a record of 12-3 (7). Dern lost the fight via 5-round majority decision.
On October 9, 2021 Mackenzie Dern faced off against Marina Rodriguez in a strawweight bout at age 28. She was coming in with a record of 11-2 (7), and Rodriguez was 34 years old and with a record of 14-1-2 (7). Dern lost the fight via 5-round unanimous decision.
On October 12, 2019 Mackenzie Dern faced off against Amanda Ribas in a strawweight bout at age 26. She was coming in with a record of 7-1 (4), and Ribas was 26 years old and with a record of 7-1 (6). Dern lost the fight via 3-round unanimous decision.