Mackens Semerzier has four losses against four opponents on his MMA record. For a list of Semerzier's best fights, refer to "Best fights of Mackens Semerzier".
On March 3, 2012 Mackens Semerzier faced off against Daniel Pineda at age 31. He was coming in with a record of 6-4 (6), and Pineda was 26 years old and with a record of 16-7 (16). Semerzier lost the fight via 1st-round submission.
On November 11, 2010 Mackens Semerzier faced off against Cub Swanson at age 30. He was coming in with a record of 5-3 (5), and Swanson was 27 years old and with a record of 14-4 (11). Semerzier lost the fight via 3-round split decision.
On August 18, 2010 Mackens Semerzier faced off against Javier Vazquez at age 29. He was coming in with a record of 5-2 (5), and Vazquez was 33 years old and with a record of 14-4 (10). Semerzier lost the fight via 2nd-round submission.
On January 10, 2010 Mackens Semerzier faced off against Deividas Taurosevičius at age 29. He was coming in with a record of 5-1 (5), and Taurosevičius was 32 years old and with a record of 11-3 (6). Semerzier lost the fight via 3-round unanimous decision.