Luke Sanders has five losses against five opponents on his MMA record. For a list of Sanders's best fights, refer to "Best fights of Luke Sanders".
On May 1, 2021 Luke Sanders faced off against Felipe Colares in a featherweight bout at age 35. He was coming in with a record of 13-5 (9), and Colares was 27 years old and with a record of 9-2 (7). Sanders lost the fight via 3-round unanimous decision.
On November 28, 2020 Luke Sanders faced off against Nate Maness in a featherweight bout at age 34. He was coming in with a record of 13-4 (9), and Maness was 29 years old and with a record of 12-1 (6). Sanders lost the fight via 2nd-round submission.
On August 25, 2018 Luke Sanders faced off against Rani Yahya in a featherweight bout at age 32. He was coming in with a record of 12-3 (8), and Yahya was 33 years old and with a record of 25-9 (18). Sanders lost the fight via 1st-round submission.
On December 9, 2017 Luke Sanders faced off against Andre Soukhamthath in a featherweight bout at age 31. He was coming in with a record of 11-2 (8), and Soukhamthath was 29 years old and with a record of 11-5 (10). Sanders lost the fight via 2nd-round TKO.
On March 4, 2017 Luke Sanders faced off against Iuri Alcântara in a featherweight bout at age 31. He was coming in with a record of 11-1 (8), and Alcântara was 36 years old and with a record of 34-7 (27). Sanders lost the fight via 2nd-round submission.