Luís Santos has 12 losses against 12 opponents on his MMA record. For a list of Santos's best fights, refer to "Best fights of Luís Santos".
On April 12, 2019 Luís Santos faced off against James Nakashima in a middleweight bout at age 39. He was coming in with a record of 65-12-1 (48). Santos lost the fight via 2nd-round TKO.
On July 13, 2018 Luís Santos faced off against Tyler McGuire in a middleweight bout at age 38. He was coming in with a record of 64-11-1 (47). Santos lost the fight via 3-round unanimous decision.
On May 26, 2017 Luís Santos faced off against Zebaztian Kadestam in a middleweight bout at age 37. He was coming in with a record of 63-10-1 (47). Santos lost the fight via 3rd-round KO.
On May 4, 2012 Luís Santos faced off against Ryan Ford in a welterweight bout at age 32. He was coming in with a record of 54-9-1 (39), and Ford was 30 years old and with a record of 17-4 (16). Santos lost the fight via 2nd-round TKO.
On October 8, 2011 Luís Santos faced off against Ben Saunders in a welterweight bout at age 31. He was coming in with a record of 54-8-1 (39), and Saunders was 28 years old and with a record of 11-3-2 (10). Santos lost the fight via 3rd-round submission.
On May 9, 2009 Luís Santos faced off against Adriano Martins at age 29. He was coming in with a record of 45-7 (33), and Martins was 26 years old and with a record of 11-4 (7). Santos lost the fight via 3-round split decision.
On September 14, 2008 Luís Santos faced off against Daniel Trindade at age 28. He was coming in with a record of 41-6 (30). Santos lost the fight via 3-round split decision.
On June 1, 2008 Luís Santos faced off against Alex Serdyukov at age 28. He was coming in with a record of 40-5 (30), and Serdyukov was 28 years old and with a record of 7-4 (6). Santos lost the fight via 1st-round TKO.
On December 20, 2007 Luís Santos faced off against Carlos Alexandre Fereira at age 27. He was coming in with a record of 40-4 (30). Santos lost the fight via 3-round unanimous decision.
On August 15, 2006 Luís Santos faced off against Yoshiyuki Yoshida at age 26. He was coming in with a record of 33-3 (26), and Yoshida was 32 years old and with a record of 2-2 (1). Santos lost the fight via 1st-round TKO.
On June 11, 2005 Luís Santos faced off against Ildemar Alcântara at age 25. He was coming in with a record of 21-2 (19), and Alcântara was 22 years old and with a record of . Santos lost the fight via 2nd-round submission.
On January 10, 2004 Luís Santos faced off against Simao Melo da Silva at age 24. He was coming in with a record of 12-1 (11). Santos lost the fight via 2nd-round TKO.