Karl Moore has four losses against four opponents on his MMA record. For a list of Moore's best fights, refer to "Best fights of Karl Moore".
On May 1, 2025 Karl Moore faced off against Antônio Carlos Júnior in a light-heavyweight bout at age 33. He was coming in with a record of 12-4 (7), and Júnior was 35 years old and with a record of 16-6 (12). Moore lost the fight via 3-round split decision.
On March 22, 2024 Karl Moore fought Corey Anderson in a light-heavyweight title fight for the Bellator World Championship title. Moore was 32 years old and with a record of 12-3 (7), and Anderson was 34 years old and with a record of 17-6 (8). Moore lost the fight via 5-round unanimous decision.
On March 24, 2018 Karl Moore fought Mauro Cerilli in a heavyweight title fight for Cerilli's Cage Warriors Championship title. Moore was 26 years old and with a record of 8-2 (6). Moore lost the fight via 1st-round KO.
On September 19, 2015 Karl Moore faced off against Paul Craig in a light-heavyweight bout at age 23. He was coming in with a record of 5-1 (4), and Craig was 27 years old and with a record of 6-0 (6). Moore lost the fight via 2nd-round submission.