James Wilks has four losses against four opponents on his MMA record. For a list of Wilks's best fights, refer to "Best fights of James Wilks".
On October 16, 2010 James Wilks faced off against Claude Patrick in a welterweight bout at age 32. He was coming in with a record of 7-4 (6), and Patrick was 30 years old and with a record of 12-1 (12). Wilks lost the fight via 3-round unanimous decision.
On November 14, 2009 James Wilks faced off against Matt Brown in a welterweight bout at age 31. He was coming in with a record of 6-3 (6), and Brown was 28 years old and with a record of 10-7 (10). Wilks lost the fight via 3rd-round TKO.
On March 11, 2006 James Wilks faced off against Patrick Speight at age 27. He was coming in with a record of 2-2 (2). Wilks lost the fight via 3-round unanimous decision.
On August 6, 2004 James Wilks faced off against Jimmy Smith at age 26. He was coming in with a record of 1-1 (1), and Smith was 26 years old and with a record of 1-0 (0). Wilks lost the fight via 1st-round submission.