Dricus du Plessis has three losses against three opponents on his MMA record. For a list of Plessis's best fights, refer to "Best fights of Dricus du Plessis".
On August 16, 2025 Dricus du Plessis met Khamzat Chimaev in a middleweight (UFC Championship) title defense fight. Plessis was 31 years old and with a record of 23-3 (20), and Chimaev was 31 years old and with a record of 14-0 (10). Plessis lost the fight via 5-round unanimous decision and lost the title.
On October 6, 2018 Dricus du Plessis met Roberto Soldić in a welterweight (KSW Championship) title defense fight. Plessis was 24 years old and with a record of 12-2 (12), and Soldić was 23 years old and with a record of 13-3 (12). Plessis lost the fight via 3rd-round KO and lost the title.
On August 30, 2014 Dricus du Plessis fought Garreth McLellan in a middleweight title fight for McLellan's EFC Championship title. Plessis was 20 years old and with a record of 4-1 (4). Plessis lost the fight via 3rd-round submission.