Dominick Cruz has four losses against four opponents on his MMA record. For a list of Cruz's best fights, refer to "Best fights of Dominick Cruz".
On August 13, 2022 Dominick Cruz faced off against Marlon Vera in a bantamweight bout at age 37. He was coming in with a record of 24-4 (8), and Vera was 29 years old and with a record of 21-7-1 (17). Cruz lost the fight via 4th-round KO.
On May 9, 2020 Dominick Cruz fought Henry Cejudo in a bantamweight title fight for Cejudo's UFC Championship title. Cruz was 35 years old and with a record of 22-3 (8), and Cejudo was 33 years old and with a record of 15-2 (7). Cruz lost the fight via 2nd-round TKO.
On December 30, 2016 Dominick Cruz met Cody Garbrandt in a bantamweight (UFC Championship) title defense fight. Cruz was 31 years old and with a record of 22-2 (8), and Garbrandt was 25 years old and with a record of 10-0 (9). Cruz lost the fight via 5-round unanimous decision and lost the title.
On March 24, 2007 Dominick Cruz fought Urijah Faber in a featherweight title fight for Faber's WEC Championship title. Cruz was 22 years old and with a record of 9-1 (5), and Faber was 27 years old and with a record of 17-1 (13). Cruz lost the fight via 1st-round submission.