Diego Lopes has seven losses against seven opponents on his MMA record. For a list of Lopes's best fights, refer to "Best fights of Diego Lopes".
On April 12, 2025 Diego Lopes fought Alexander Volkanovski in a featherweight title fight for the UFC Championship title. Lopes was 30 years old and with a record of 26-7 (22), and Volkanovski was 36 years old and with a record of 26-4 (16). Lopes lost the fight via 5-round unanimous decision.
On May 6, 2023 Diego Lopes faced off against Movsar Evloev in a featherweight bout at age 28. He was coming in with a record of 21-6 (19), and Evloev was 29 years old and with a record of 16-0 (7). Lopes lost the fight via 3-round unanimous decision.
On October 17, 2021 Diego Lopes faced off against Nate Richardson in a featherweight bout at age 26. He was coming in with a record of 19-5 (17). Lopes lost the fight via 5-round split decision.
On August 31, 2021 Diego Lopes faced off against Joanderson Brito in a featherweight bout at age 26. He was coming in with a record of 19-4 (17). Lopes lost the fight via 3-round unanimous decision.
On January 13, 2018 Diego Lopes faced off against Amir Elzhurkaev in a bantamweight bout at age 23. He was coming in with a record of 12-3 (12). Lopes lost the fight via 2nd-round KO.
On April 16, 2014 Diego Lopes faced off against Rodrigo Praia at age 19. He was coming in with a record of 3-2 (3). Lopes lost the fight via 2nd-round TKO.
On November 8, 2013 Diego Lopes faced off against Thiago Silva at age 18. He was coming in with a record of 3-1 (3). Lopes lost the fight via 3-round split decision.