Here is a list of Lewis's best fights. For a list of Lewis's losses, refer to "Derrick Lewis Losses".
On July 29, 2023 Derrick Lewis faced off against Marcos Rogério de Lima in a heavyweight bout at age 38. He was coming in with a record of 27-11 (23), and Lima was 38 years old and with a record of 21-8-1 (17). Lewis stopped Marcos Rogério de Lima via TKO.
On July 12, 2025 Derrick Lewis faced off against Tallison Teixeira in a heavyweight bout at age 40. He was coming in with a record of 29-12 (25), and Teixeira was 25 years old and with a record of 8-0 (8). Lewis stopped Tallison Teixeira via TKO.
On February 20, 2021 Derrick Lewis faced off against Curtis Blaydes in a heavyweight bout at age 36. He was coming in with a record of 25-7 (21), and Blaydes was 30 years old and with a record of 14-2 (10). Lewis stopped Curtis Blaydes via KO.
On February 18, 2018 Derrick Lewis faced off against Marcin Tybura in a heavyweight bout at age 33. He was coming in with a record of 19-5 (18), and Tybura was 32 years old and with a record of 16-3 (12). Lewis stopped Marcin Tybura via KO.
On May 11, 2024 Derrick Lewis faced off against Rodrigo Nascimento in a heavyweight bout at age 39. He was coming in with a record of 28-12 (24), and Nascimento was 31 years old and with a record of 11-1 (8). Lewis stopped Rodrigo Nascimento via TKO.
On February 6, 2016 Derrick Lewis faced off against Damian Grabowski in a heavyweight bout at age 30. He was coming in with a record of 14-4 (14), and Grabowski was 35 years old and with a record of 20-2 (17). Lewis stopped Damian Grabowski via TKO.
On December 18, 2021 Derrick Lewis faced off against Chris Daukaus in a heavyweight bout at age 36. He was coming in with a record of 26-8 (22), and Daukaus was 32 years old and with a record of 12-3 (11). Lewis stopped Chris Daukaus via KO.
On April 10, 2016 Derrick Lewis faced off against Gabriel Gonzaga in a heavyweight bout at age 31. He was coming in with a record of 15-4 (15), and Gonzaga was 36 years old and with a record of 17-10 (16). Lewis stopped Gabriel Gonzaga via KO.
On July 6, 2014 Derrick Lewis faced off against Guto Inocente in a heavyweight bout at age 29. He was coming in with a record of 11-2 (11), and Inocente was 28 years old and with a record of 6-2 (5). Lewis stopped Guto Inocente via KO.
On February 19, 2017 Derrick Lewis faced off against Travis Browne in a heavyweight bout at age 32. He was coming in with a record of 18-4 (17), and Browne was 34 years old and with a record of 18-5-1 (16). Lewis stopped Travis Browne via KO.