Cynthia Calvillo has six losses against six opponents on her MMA record. For a list of Calvillo's best fights, refer to "Best fights of Cynthia Calvillo".
On April 8, 2023 Cynthia Calvillo faced off against Lupita Godinez in a strawweight bout at age 35. She was coming in with a record of 9-6-1 (5). Calvillo lost the fight via 3-round split decision.
On August 13, 2022 Cynthia Calvillo faced off against Nina Nunes in a flyweight bout at age 35. She was coming in with a record of 9-5-1 (5). Calvillo lost the fight via 3-round split decision.
On November 13, 2021 Cynthia Calvillo faced off against Andrea Lee in a flyweight bout at age 34. She was coming in with a record of 9-4-1 (5), and Lee was 32 years old and with a record of 12-5 (7). Calvillo lost the fight via 2nd-round TKO.
On September 25, 2021 Cynthia Calvillo faced off against Jéssica Andrade in a flyweight bout at age 34. She was coming in with a record of 9-3-1 (5), and Andrade was 30 years old and with a record of 21-9 (15). Calvillo lost the fight via 1st-round TKO.
On November 21, 2020 Cynthia Calvillo faced off against Katlyn Chookagian in a flyweight bout at age 33. She was coming in with a record of 9-2-1 (5). Calvillo lost the fight via 3-round unanimous decision.
On December 30, 2017 Cynthia Calvillo faced off against Carla Esparza in a strawweight bout at age 30. She was coming in with a record of 6-1 (4), and Esparza was 30 years old and with a record of 12-4 (7). Calvillo lost the fight via 3-round unanimous decision.