Here is a list of Guida's best fights. For a list of Guida's losses, refer to "Clay Guida Losses".
On March 21, 2010 Clay Guida faced off against Shannon Gugerty in a lightweight bout at age 28. He was coming in with a record of 26-11 (17), and Gugerty was 28 years old and with a record of 12-4 (12). Guida stopped Shannon Gugerty via submission.
On August 7, 2010 Clay Guida faced off against Rafael dos Anjos in a lightweight bout at age 28. He was coming in with a record of 27-11 (18), and Anjos was 25 years old and with a record of 14-4 (8). Guida stopped Rafael dos Anjos via TKO.
On March 10, 2006 Clay Guida fought Josh Thomson in a lightweight title fight for Thomson's Strikeforce Championship title. Guida was 24 years old and with a record of 19-4 (14), and Thomson was 27 years old and with a record of 8-1 (6). Guida won the fight via 5-round unanimous decision and is crowned the new Strikeforce lightweight champion.
On November 11, 2017 Clay Guida faced off against Joe Lauzon in a lightweight bout at age 35. He was coming in with a record of 34-17 (20), and Lauzon was 33 years old and with a record of 27-13 (24). Guida stopped Joe Lauzon via TKO.
On April 2, 2008 Clay Guida faced off against Samy Schiavo in a lightweight bout at age 26. He was coming in with a record of 23-9 (16). Guida stopped Samy Schiavo via TKO.
On December 4, 2021 Clay Guida faced off against Leonardo Santos in a lightweight bout at age 39. He was coming in with a record of 37-21 (21), and Santos was 41 years old and with a record of 18-4-1 (10). Guida stopped Leonardo Santos via submission.
On January 26, 2013 Clay Guida faced off against Hatsu Hioki in a featherweight bout at age 31. He was coming in with a record of 30-13 (19), and Hioki was 29 years old and with a record of 26-5-2 (14). Guida won the fight via 3-round split decision.
On April 4, 2015 Clay Guida faced off against Robbie Peralta in a featherweight bout at age 33. He was coming in with a record of 32-15 (19), and Peralta was 29 years old and with a record of 18-5 (15). Guida won the fight via 3-round unanimous decision.
On October 14, 2006 Clay Guida faced off against Justin James in a lightweight bout at age 24. He was coming in with a record of 21-6 (15). Guida stopped Justin James via submission.
On January 1, 2011 Clay Guida faced off against Takanori Gomi in a lightweight bout at age 29. He was coming in with a record of 28-11 (19), and Gomi was 32 years old and with a record of 32-6 (17). Guida stopped Takanori Gomi via submission.