Here is a list of Guida's best fights. For a list of Guida's losses, refer to "Clay Guida Losses".
On November 11, 2017 Clay Guida faced off against Joe Lauzon in a lightweight bout at age 35. He was coming in with a record of 34-17 (20), and Lauzon was 33 years old and with a record of 27-13 (24). Guida stopped Joe Lauzon via TKO.
On December 4, 2021 Clay Guida faced off against Leonardo Santos in a lightweight bout at age 39. He was coming in with a record of 37-21 (21), and Santos was 41 years old and with a record of 18-4-1 (10). Guida stopped Leonardo Santos via submission.
On March 21, 2010 Clay Guida faced off against Shannon Gugerty in a lightweight bout at age 28. He was coming in with a record of 26-11 (17), and Gugerty was 28 years old and with a record of 12-4 (12). Guida stopped Shannon Gugerty via submission.
On January 1, 2011 Clay Guida faced off against Takanori Gomi in a lightweight bout at age 29. He was coming in with a record of 28-11 (19), and Gomi was 32 years old and with a record of 32-6 (17). Guida stopped Takanori Gomi via submission.
On August 7, 2010 Clay Guida faced off against Rafael dos Anjos in a lightweight bout at age 28. He was coming in with a record of 27-11 (18), and Anjos was 25 years old and with a record of 14-4 (8). Guida stopped Rafael dos Anjos via TKO.
On October 14, 2006 Clay Guida faced off against Justin James in a lightweight bout at age 24. He was coming in with a record of 21-6 (15). Guida stopped Justin James via submission.
On March 10, 2006 Clay Guida fought Josh Thomson in a lightweight title fight for Thomson's Strikeforce Championship title. Guida was 24 years old and with a record of 19-4 (14), and Thomson was 27 years old and with a record of 8-1 (6). Guida won the fight via 5-round unanimous decision and is crowned the new Strikeforce lightweight champion.
On June 25, 2017 Clay Guida faced off against Erik Koch in a lightweight bout at age 35. He was coming in with a record of 33-17 (19), and Koch was 28 years old and with a record of 15-4 (12). Guida won the fight via 3-round unanimous decision.
On February 6, 2021 Clay Guida faced off against Michael Johnson in a lightweight bout at age 39. He was coming in with a record of 36-20 (20), and Johnson was 34 years old and with a record of 19-16 (10). Guida won the fight via 3-round unanimous decision.
On January 31, 2009 Clay Guida faced off against Nate Diaz in a lightweight bout at age 27. He was coming in with a record of 25-9 (16), and Diaz was 23 years old and with a record of 10-2 (9). Guida won the fight via 3-round split decision.
