Cain Velasquez has three losses against three opponents on his MMA record. For a list of Velasquez's best fights, refer to "Best fights of Cain Velasquez".
On February 17, 2019 Cain Velasquez faced off against Francis Ngannou in a heavyweight bout at age 36. He was coming in with a record of 14-3 (12), and Ngannou was 32 years old and with a record of 12-3 (12). Velasquez lost the fight via 1st-round KO.
On June 13, 2015 Cain Velasquez met Fabrício Werdum in a heavyweight (UFC Championship) title defense fight. Velasquez was 32 years old and with a record of 13-2 (11), and Werdum was 37 years old and with a record of 19-5-1 (15). Velasquez lost the fight via 3rd-round submission and lost the title.
On November 12, 2011 Cain Velasquez met Junior dos Santos in a heavyweight (UFC Championship) title defense fight. Velasquez was 29 years old and with a record of 9-1 (8), and Santos was 27 years old and with a record of 13-1 (11). Velasquez lost the fight via 1st-round KO and lost the title.