Brian Melancon has three losses against three opponents on his MMA record. For a list of Melancon's best fights, refer to "Best fights of Brian Melancon".
On August 28, 2013 Brian Melancon faced off against Kelvin Gastelum at age 31. He was coming in with a record of 7-3 (5), and Gastelum was 21 years old and with a record of 7-0 (6). Melancon lost the fight via 1st-round submission.
On June 18, 2011 Brian Melancon faced off against Isaac Vallie-Flagg at age 29. He was coming in with a record of 5-2 (4), and Vallie-Flagg was 33 years old and with a record of 11-3-1 (8). Melancon lost the fight via 3-round split decision.
On May 27, 2010 Brian Melancon faced off against Adam Schindler at age 27. He was coming in with a record of 3-1 (3), and Schindler was 27 years old and with a record of 6-2 (5). Melancon lost the fight via 3-round unanimous decision.