Bobby Southworth has six losses against six opponents on his MMA record. For a list of Southworth's best fights, refer to "Best fights of Bobby Southworth".
On November 21, 2008 Bobby Southworth met Renato Sobral in a light-heavyweight (Strikeforce Championship) title defense fight. Southworth was 38 years old and with a record of 9-6 (7), and Sobral was 33 years old and with a record of 33-8 (20). Southworth lost the fight via 1st-round TKO and lost the title.
On November 16, 2007 Bobby Southworth faced off against Anthony Ruiz in a light-heavyweight bout at age 37. He was coming in with a record of 8-5 (7), and Ruiz was 30 years old and with a record of 17-10 (13). Southworth lost the fight via 2nd-round TKO.
On April 9, 2005 Bobby Southworth faced off against Sam Hoger at age 35. He was coming in with a record of 6-4 (6), and Hoger was 24 years old and with a record of 4-0 (4). Southworth lost the fight via 3-round unanimous decision.
On March 29, 2002 Bobby Southworth faced off against David Pa'aluhi at age 32. He was coming in with a record of 4-3 (4). Southworth lost the fight via 1st-round KO.
On March 25, 2001 Bobby Southworth faced off against Vitor Belfort at age 31. He was coming in with a record of 3-2 (3), and Belfort was 23 years old and with a record of 8-2 (6). Southworth lost the fight via 1st-round submission.
On May 28, 1999 Bobby Southworth faced off against Jason Godsey at age 29. He was coming in with a record of 0-1 (0). Southworth lost the fight via 2nd-round submission.