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Marco Antonio Barrera had a total of seven losses in his professional boxing career — five of them in title bouts and two in non-title bouts. He suffered his first loss against Junior Jones via 5th round TKO on November 22, 1996, which ended his 43-fight win streak. He has been stopped two times and lost five times via decision.
Amir Khan, Juan Manuel Márquez, Manny Pacquiao, Érik Morales, and Junior Jones are the five boxers who have beaten Barrera.
This is the first loss in Marco Antonio Barrera's career. Barrera lost to American boxer Junior Jones via 5th round TKO on . He was defending his super-bantamweight WBO title, he was 22 years old with a record of 43-0. Jones was 25 years old with a record of 42-2.
On Barrera lost to American boxer Junior Jones in the rematch via 12 round unanimous decision. He was fighting for Jones' super-bantamweight WBO title, he was 23 years old with a record of 43-1. Jones was 26 years old with a record of 43-2.
On Barrera lost to fellow Mexican boxer Érik Morales via 12 round split decision. He was defending his super-bantamweight WBO title, and fighting for Morales' super-bantamweight WBC title, he was 26 years old with a record of 49-2. Morales was 23 years old with a record of 35-0.
On Barrera lost to Filipino boxer Manny Pacquiao via 11th round TKO. He was defending his featherweight The Ring title, he was 29 years old with a record of 57-3. Pacquiao was 24 years old with a record of 37-2-1.
On Barrera lost to fellow Mexican boxer Juan Manuel Márquez via 12 round unanimous decision. He was defending his super-featherweight WBC title, he was 33 years old with a record of 63-4. Márquez was also 33 years old, with a record of 46-3-1.
On Barrera lost to Filipino boxer Manny Pacquiao in a rematch via 12 round unanimous decision in a non-title bout. He was 33 years old with a record of 63-5. Pacquiao was 28 years old with a record of 44-3-2.
On Barrera lost to British boxer Amir Khan via 5 round technical decision in a non-title bout. He was 35 years old with a record of 65-6. Khan was 22 years old with a record of 19-1.