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Juan Manuel López had a total of six losses in his professional boxing career — three of them in title bouts and three in non-title bouts. He suffered his first loss against Orlando Salido via 8th round TKO on April 16, 2011, which ended his 30-fight win streak. All of López' losses came via stoppage.
Jayson Vélez, Jesús Cuellar, Francisco Vargas, Mikey Garcia, and Orlando Salido are the five boxers who have beaten López.
This is the first loss in Juan Manuel López' career. López lost to Mexican boxer Orlando Salido via 8th round TKO on . He was defending his featherweight WBO title, he was 27 years old with a record of 30-0. Salido was 32 years old with a record of 35-11-2.
On López lost to Mexican boxer Orlando Salido in a rematch via 10th round TKO. He was fighting for Salido's featherweight WBO title, he was 28 years old with a record of 31-1. Salido was 33 years old with a record of 38-11-2.
On López lost to American boxer Mikey Garcia via 4th round TKO. He and Garcia were fighting for the vacant featherweight WBO title. He was 29 years old with a record of 33-2. Garcia was 25 years old with a record of 31-0.
On López lost to Mexican boxer Francisco Vargas via 3rd round RTD in a non-title bout. He was 31 years old with a record of 34-3. Vargas was 29 years old with a record of 19-0-1.
On López lost to Argentinian boxer Jesús Cuellar via 2nd round KO in a non-title bout. He was 31 years old with a record of 34-4. Cuellar was 27 years old with a record of 24-1.
On López lost to Jayson Vélez via 12th round TKO in a non-title bout. He was 34 years old with a record of 35-5.