Wilfredo Vázquez Jr. has seven losses against seven opponents on his boxing record. For a list of Vázquez Jr.'s best fights, refer to "Best fights of Wilfredo Vázquez Jr.".
On October 29, 2016 Wilfredo Vázquez Jr. faced off against Juan Manuel López at age 32. He was coming in with a record of 24-7-1 (19), and López was 33 years old and with a record of 34-5 (31). Vázquez Jr. lost the fight via 11th-round TKO.
On December 5, 2015 Wilfredo Vázquez Jr. faced off against Rafael Rivera in a featherweight bout at age 31. He was coming in with a record of 24-6-1 (19). Vázquez Jr. lost the fight via 10-round split decision.
On June 6, 2015 Wilfredo Vázquez Jr. faced off against Fernando Vargas at age 30. He was coming in with a record of 24-5-1 (19). Vázquez Jr. lost the fight via 8-round unanimous decision.
On June 7, 2014 Wilfredo Vázquez Jr. faced off against Marvin Sonsona in a featherweight bout at age 29. He was coming in with a record of 23-4-1 (19). Vázquez Jr. lost the fight via 10-round split decision.
On April 6, 2013 Wilfredo Vázquez Jr. faced off against Yasutaka Ishimoto in a super-bantamweight bout at age 28. He was coming in with a record of 22-3-1 (19). Vázquez Jr. lost the fight via 10-round majority decision.
On February 4, 2012 Wilfredo Vázquez Jr. fought Nonito Donaire in a super-bantamweight world-title fight for the WBO title. Vázquez Jr. was 27 years old and with a record of 21-2-1 (18), and Donaire was 29 years old and with a record of 27-1 (18). Vázquez Jr. lost the fight via 12-round split decision.
On May 7, 2011 Wilfredo Vázquez Jr. met Jorge Arce in a super-bantamweight (WBO) world-title defense fight. Vázquez Jr. was 26 years old and with a record of 20-1-1 (17), and Arce was 31 years old and with a record of 56-6-2 (43). Vázquez Jr. lost the fight via 12th-round TKO and lost the title.
