Román González has four losses against two opponents on his boxing record. For a list of González's best fights, refer to "Best fights of Román González".
On December 3, 2022 Román González fought Juan Francisco Estrada in a super-flyweight world-title fight for the The Ring and WBC titles. González was 35 years old and with a record of 51-4 (41), and Estrada was 32 years old and with a record of 43-3 (28). González lost the fight via 12-round majority decision.
On March 13, 2021 Román González, the WBA (Super) champion, met Juan Francisco Estrada, the WBC and The Ring champion, in a super-flyweight world-title unification fight. González was 33 years old and with a record of 50-3 (41), and Estrada was 30 years old and with a record of 41-3 (28). González lost the fight via 12-round split decision and lost his title.
On September 9, 2017 Román González fought Srisaket Sor Rungvisai in a super-flyweight world-title fight for Rungvisai's WBC title. González was 30 years old and with a record of 46-2 (38), and Rungvisai was 30 years old and with a record of 43-4-1 (39). González lost the fight via 4th-round KO.
On March 18, 2017 Román González met Srisaket Sor Rungvisai in a super-flyweight (WBC) world-title defense fight. González was 29 years old and with a record of 46-1 (38), and Rungvisai was 30 years old and with a record of 42-4-1 (39). González lost the fight via 12-round majority decision and lost the title.