Rene Mark Cuarto has four losses against four opponents on his boxing record. For a list of Cuarto's best fights, refer to "Best fights of Rene Mark Cuarto".
On April 16, 2023 Rene Mark Cuarto fought Ginjiro Shigeoka in a strawweight world-title fight for the IBF title. Cuarto was 26 years old and with a record of 21-4-2 (12), and Shigeoka was 23 years old and with a record of 8-0 (6). Cuarto lost the fight via 9th-round KO.
On July 1, 2022 Rene Mark Cuarto met Daniel Valladares in a strawweight (IBF) world-title defense fight. Cuarto was 25 years old and with a record of 20-3-2 (11), and Valladares was 28 years old and with a record of 25-3-1 (15). Cuarto lost the fight via 12-round split decision and lost the title.
On March 23, 2019 Rene Mark Cuarto faced off against Samuel Salva at age 22. He was coming in with a record of 16-2-1 (9). Cuarto lost the fight via 12-round unanimous decision.
On January 31, 2015 Rene Mark Cuarto faced off against Jerald Paclar at age 18. He was coming in with a record of 3-1 (1). Cuarto lost the fight via 6-round unanimous decision.