Mikkel Kessler has three losses against three opponents on his boxing record. For a list of Kessler's best fights, refer to "Best fights of Mikkel Kessler".
On May 25, 2013 Mikkel Kessler, the WBA (Regular) champion, met Carl Froch, the IBF champion, in a super-middleweight world-title unification fight. Kessler was 34 years old and with a record of 46-3 (35), and Froch was 35 years old and with a record of 30-2 (22). Kessler lost the fight via 12-round unanimous decision and lost his title.
On November 21, 2009 Mikkel Kessler met Andre Ward in a super-middleweight () world-title defense fight. Kessler was 30 years old and with a record of 42-2 (32), and Ward was 25 years old and with a record of 20-0 (13). Kessler lost the fight via 11-round technical decision and lost the titles.
On November 3, 2007 Mikkel Kessler, the WBA (Super) and WBC champion, met Joe Calzaghe, the WBO and The Ring champion, in a super-middleweight world-title unification fight. Kessler was 28 years old and with a record of 39-1 (29), and Calzaghe was 35 years old and with a record of 43-0 (32). Kessler lost the fight via 12-round unanimous decision and lost his titles.