Melvin Jerusalem has three losses against three opponents on his boxing record. For a list of Jerusalem's best fights, refer to "Best fights of Melvin Jerusalem".
On May 27, 2023 Melvin Jerusalem met Oscar Collazo in a strawweight (WBO) world-title defense fight. Jerusalem was 29 years old and with a record of 20-3 (12), and Collazo was 26 years old and with a record of 6-0 (4). Jerusalem lost the fight via 7th-round retirement and lost the title.
On July 8, 2017 Melvin Jerusalem faced off against Joey Canoy at age 23. He was coming in with a record of 11-2 (7). Jerusalem lost the fight via 10-round unanimous decision.
On January 25, 2017 Melvin Jerusalem fought Wanheng Menayothin in a strawweight world-title fight for Menayothin's WBC title. Jerusalem was 22 years old and with a record of 11-1 (7), and Menayothin was 31 years old and with a record of 44-0 (17). Jerusalem lost the fight via 12-round unanimous decision.