Lou Del Valle has six losses against six opponents on his boxing record. For a list of Del Valle's best fights, refer to "Best fights of Lou Del Valle".
On July 18, 2008 Lou Del Valle faced off against DeLeon Tinsley at age 40. He was coming in with a record of 36-6-1 (22). Del Valle lost the fight via 8-round unanimous decision.
On September 14, 2007 Lou Del Valle faced off against Johny Jensen in a cruiserweight bout at age 39. He was coming in with a record of 35-5-1 (22). Del Valle lost the fight via 12-round unanimous decision.
On October 20, 2006 Lou Del Valle faced off against Zack Page at age 38. He was coming in with a record of 35-4-1 (22). Del Valle lost the fight via 10-round unanimous decision.
On July 13, 2002 Lou Del Valle fought Bruno Girard in a light-heavyweight world-title fight for Girard's WBA title. Del Valle was 34 years old and with a record of 31-3-1 (21), and Girard was 31 years old and with a record of 41-3-2 (7). Del Valle lost the fight via 12-round split decision.
On July 18, 1998 Lou Del Valle fought Roy Jones Jr. in a light-heavyweight world-title fight for Jones Jr.'s WBC title. Del Valle was 30 years old and with a record of 27-2 (19), and Jones Jr. was 29 years old and with a record of 36-1 (31). Del Valle lost the fight via 12-round unanimous decision.
On April 20, 1996 Lou Del Valle fought Virgil Hill in a light-heavyweight world-title fight for Hill's WBA title. Del Valle was 27 years old and with a record of 22-1 (15), and Hill was 32 years old and with a record of 41-1 (20). Del Valle lost the fight via 12-round unanimous decision.