Juan Carlos Payano has five losses against five opponents on his boxing record. For a list of Payano's best fights, refer to "Best fights of Juan Carlos Payano".
On December 19, 2020 Juan Carlos Payano faced off against Gary Antonio Russell in a bantamweight bout at age 36. He was coming in with a record of 21-5 (9), and Russell was 27 years old and with a record of 17-0 (12). Payano lost the fight via 7-round technical decision.
On September 26, 2020 Juan Carlos Payano faced off against Daniel Roman in a bantamweight bout at age 36. He was coming in with a record of 21-4 (9), and Roman was 30 years old and with a record of 27-3-1 (10). Payano lost the fight via 12-round unanimous decision.
On July 20, 2019 Juan Carlos Payano faced off against Luis Nery in a bantamweight bout at age 35. He was coming in with a record of 21-3 (9), and Nery was 24 years old and with a record of 29-0 (23). Payano lost the fight via 9th-round KO.
On October 7, 2018 Juan Carlos Payano fought Naoya Inoue in a bantamweight world-title fight for Inoue's WBA (Regular) title. Payano was 34 years old and with a record of 20-2 (9), and Inoue was 25 years old and with a record of 16-0 (14). Payano lost the fight via 1st-round KO.
On June 18, 2016 Juan Carlos Payano met Rau'shee Warren in a bantamweight (WBA (Undisputed)) world-title defense fight. Payano was 32 years old and with a record of 17-1 (8). Payano lost the fight via 12-round majority decision and lost the title.
