Here is a list of Cruz's best fights. For a list of Cruz's losses, refer to "Isaac Cruz Losses".
On March 13, 2021 Isaac Cruz faced off against Jose Matias Romero at age 22. He was coming in with a record of 21-1-1 (15), and Romero was 24 years old and with a record of 24-0 (8). Cruz won the fight via 12-round unanimous decision.
On June 19, 2021 Isaac Cruz faced off against Francisco Vargas at age 23. He was coming in with a record of 22-1-1 (15), and Vargas was 36 years old and with a record of 27-2-2 (19). Cruz won the fight via 10-round unanimous decision.
On November 10, 2018 Isaac Cruz faced off against Jose Felix at age 20. He was coming in with a record of 16-1-1 (13), and Felix was 26 years old and with a record of 37-3-1 (28). Cruz stopped Jose Felix via TKO.
On February 1, 2025 Isaac Cruz faced off against Angel Fierro in a super-lightweight bout at age 26. He was coming in with a record of 27-3-1 (18), and Fierro was 31 years old and with a record of 23-2-2 (18). Cruz won the fight via 10-round unanimous decision.
On March 30, 2024 Isaac Cruz fought Rolando Romero in a super-lightweight world-title fight for Romero's WBA title. Cruz was 25 years old and with a record of 26-2-1 (18), and Romero was 28 years old and with a record of 15-1 (13). Cruz stopped Rolando Romero via 8th-round TKO and is crowned the new super-lightweight world champion.
On April 16, 2022 Isaac Cruz faced off against Yuriorkis Gamboa in a lightweight bout at age 23. He was coming in with a record of 23-2-1 (16), and Gamboa was 40 years old and with a record of 30-4 (18). Cruz stopped Yuriorkis Gamboa via TKO.
On September 4, 2022 Isaac Cruz faced off against Eduardo Ramirez in a lightweight bout at age 24. He was coming in with a record of 24-2-1 (17), and Ramirez was 29 years old and with a record of 27-2-3 (12). Cruz stopped Eduardo Ramirez via KO.
On July 29, 2023 Isaac Cruz faced off against Giovanni Cabrera in a lightweight bout at age 25. He was coming in with a record of 25-2-1 (17), and Cabrera was 29 years old and with a record of 21-0 (7). Cruz won the fight via 12-round split decision.
On July 19, 2025 Isaac Cruz faced off against Omar Salcido Gamez in a super-lightweight bout at age 27. He was coming in with a record of 28-3-1 (18), and Gamez was 25 years old and with a record of 20-2 (14). Cruz won the fight via 10-round unanimous decision.
