Isaac Chamberlain has three losses against three opponents on his boxing record. For a list of Chamberlain's best fights, refer to "Best fights of Isaac Chamberlain".
On June 15, 2024 Isaac Chamberlain faced off against Jack Massey in a cruiserweight bout at age 30. He was coming in with a record of 16-3 (8), and Massey was 31 years old and with a record of 21-2 (12). Chamberlain lost the fight via 12-round unanimous decision.
On July 30, 2022 Isaac Chamberlain faced off against Chris Billam-Smith in a cruiserweight bout at age 28. He was coming in with a record of 14-2 (8), and Billam-Smith was 31 years old and with a record of 15-1 (11). Chamberlain lost the fight via 12-round unanimous decision.
On February 3, 2018 Isaac Chamberlain faced off against Lawrence Okolie in a cruiserweight bout at age 23. He was coming in with a record of 9-1 (4), and Okolie was 25 years old and with a record of 7-0 (6). Chamberlain lost the fight via 10-round unanimous decision.
