Guillermo Rigondeaux has three losses against three opponents on his boxing record. For a list of Rigondeaux's best fights, refer to "Best fights of Guillermo Rigondeaux".
On February 26, 2022 Guillermo Rigondeaux faced off against Vincent Astrolabio in a bantamweight bout at age 41. He was coming in with a record of 20-3 (13), and Astrolabio was 24 years old and with a record of 16-3 (12). Rigondeaux lost the fight via 10-round unanimous decision.
On August 14, 2021 Guillermo Rigondeaux fought John Riel Casimero in a bantamweight world-title fight for Casimero's WBO title. Rigondeaux was 40 years old and with a record of 20-2 (13), and Casimero was 32 years old and with a record of 30-4 (21). Rigondeaux lost the fight via 12-round split decision.
On December 9, 2017 Guillermo Rigondeaux fought Vasyl Lomachenko in a super-featherweight world-title fight for Lomachenko's WBO title. Rigondeaux was 37 years old and with a record of 17-1 (11), and Lomachenko was 29 years old and with a record of 9-1 (7). Rigondeaux lost the fight via 6th-round retirement.
