Giovani Santillan has one loss against one opponent on his boxing record. For a list of Santillan's best fights, refer to "Best fights of Giovani Santillan".
On May 18, 2024 Giovani Santillan faced off against Brian Norman Jr. in a welterweight bout at age 32. He was coming in with a record of 32-1 (17), and Norman Jr. was 23 years old and with a record of 25-0 (19). Santillan lost the fight via 10th-round KO.