Here is a list of Santillan's best fights. For a list of Santillan's losses, refer to "Giovani Santillan Losses".
On October 21, 2023 Giovani Santillan faced off against Alexis Rocha in a welterweight bout at age 31. He was coming in with a record of 32-0 (17), and Rocha was 26 years old and with a record of 23-1 (15). Santillan stopped Alexis Rocha via KO.
On December 7, 2024 Giovani Santillan faced off against Fredrick Lawson in a welterweight bout at age 33. He was coming in with a record of 33-1 (18), and Lawson was 35 years old and with a record of 30-5 (22). Santillan stopped Fredrick Lawson via retirement.
On June 16, 2020 Giovani Santillan faced off against Antonio DeMarco at age 28. He was coming in with a record of 26-0 (15), and DeMarco was 34 years old and with a record of 33-8-1 (24). Santillan won the fight via 10-round majority decision.
On July 7, 2017 Giovani Santillan faced off against Sammy Valentin in a welterweight bout at age 25. He was coming in with a record of 22-0 (12). Santillan stopped Sammy Valentin via TKO.
On April 27, 2018 Giovani Santillan faced off against Alejandro Barboza in a welterweight bout at age 26. He was coming in with a record of 24-0 (14). Santillan stopped Alejandro Barboza via KO.
