Francisco Vargas has five losses against four opponents on his boxing record. For a list of Vargas's best fights, refer to "Best fights of Francisco Vargas".
On November 18, 2022 Francisco Vargas faced off against Guillermo Avila Godinez in a super-featherweight bout at age 37. He was coming in with a record of 27-5-2 (19). Vargas lost the fight via 10-round split decision.
On April 16, 2022 Francisco Vargas faced off against Jose Valenzuela in a super-featherweight bout at age 37. He was coming in with a record of 27-4-2 (19), and Valenzuela was 22 years old and with a record of 11-0 (7). Vargas lost the fight via 1st-round KO.
On June 19, 2021 Francisco Vargas faced off against Isaac Cruz in a lightweight bout at age 36. He was coming in with a record of 27-3-2 (19), and Cruz was 23 years old and with a record of 21-1-1 (15). Vargas lost the fight via 10-round unanimous decision.
On May 11, 2019 Francisco Vargas fought Miguel Berchelt in a super-featherweight world-title fight for Berchelt's WBC title. Vargas was 34 years old and with a record of 25-2-2 (18), and Berchelt was 27 years old and with a record of 35-1 (31). Vargas lost the fight via 6th-round retirement.
On January 28, 2017 Francisco Vargas met Miguel Berchelt in a super-featherweight (WBC) world-title defense fight. Vargas was 32 years old and with a record of 23-1-2 (17), and Berchelt was 25 years old and with a record of 30-1 (27). Vargas lost the fight via 11th-round KO and lost the title.