Francisco Rodríguez Jr. has six losses against six opponents on his boxing record. For a list of Rodríguez Jr.'s best fights, refer to "Best fights of Francisco Rodríguez Jr.".
On November 1, 2022 Francisco Rodríguez Jr. faced off against Junto Nakatani in a super-flyweight bout at age 29. He was coming in with a record of 36-6-1 (25), and Nakatani was 24 years old and with a record of 23-0 (18). Rodríguez Jr. lost the fight via 10-round unanimous decision.
On September 1, 2021 Francisco Rodríguez Jr. fought Kazuto Ioka in a super-flyweight world-title fight for Ioka's WBO title. Rodríguez Jr. was 28 years old and with a record of 34-5-1 (24), and Ioka was 32 years old and with a record of 26-2 (15). Rodríguez Jr. lost the fight via 12-round unanimous decision.
On December 5, 2015 Francisco Rodríguez Jr. faced off against Moisés Fuentes in a light-flyweight bout at age 22. He was coming in with a record of 19-4-1 (13). Rodríguez Jr. lost the fight via 12-round split decision.
On July 11, 2015 Francisco Rodríguez Jr. fought Donnie Nietes in a light-flyweight world-title fight for Nietes' WBO and The Ring titles. Rodríguez Jr. was 22 years old and with a record of 19-3-1 (13), and Nietes was 33 years old and with a record of 35-1-4 (21). Rodríguez Jr. lost the fight via 12-round unanimous decision.
On September 21, 2013 Francisco Rodríguez Jr. faced off against Román González in a light-flyweight bout at age 20. He was coming in with a record of 14-2 (12), and González was 26 years old and with a record of 35-0 (29). Rodríguez Jr. lost the fight via 7th-round TKO.
On May 18, 2012 Francisco Rodríguez Jr. faced off against Salvador Arias at age 18. He was coming in with a record of 8-1 (7). Rodríguez Jr. lost the fight via 6-round unanimous decision.
