Here is a list of Rodríguez Jr.'s best fights. For a list of Rodríguez Jr.'s losses, refer to "Francisco Rodríguez Jr. Losses".
On March 22, 2014 Francisco Rodríguez Jr. fought Merlito Sabillo in a strawweight world-title fight for Sabillo's WBO title. Rodríguez Jr. was 20 years old and with a record of 17-2 (13). Rodríguez Jr. stopped Merlito Sabillo via 10th-round TKO and is crowned the new strawweight world champion.
On November 30, 2019 Francisco Rodríguez Jr. faced off against Jose Maria Cardenas in a super-flyweight bout at age 26. He was coming in with a record of 33-4-1 (24). Rodríguez Jr. stopped Jose Maria Cardenas via KO.